The subseries contains letters to state and church authorities of the Republic sent in the 16th century by popes and cardinals of the Papal States, Hungarian and other kings, or other authorities of that period, such as the authorities of the Republic of Venice, the Venetian Captain of the Gulf and the Grand Master of Malta. The most numerous letters are the letters written by cardinals and other church dignitaries, state dignitaries, mainly from Italian cities, and letters written by diplomatic and consular representatives of the Republic sent to the authorities of the Republic. The subseries also contains letters from local authorities from the territory of the Dubrovnik Republic, various correspondence between merchants and other private persons and some documents related to judicial investigations.

In the correspondence of Bartolomeo Borgiani, a prominent Florentine merchant who lived in Dubrovnik, several letters of Jewish people living in the Ottoman territory and Venice can also be found. The names indicated in this correspondence are, for example, Leon de Medina and Joseph Lindo from Skopje and Jacob Tobi from Venice (e.g., vol. 467.1, no. 3). Among documents that are related to judicial investigations, there is one reference to Jews: in 1561, David Mazaod arbitrated in a conflict between Samuel Coen of Istanbul and a Dubrovnik ambassador Šimun Benessa (vol. 466, no. 18).