The fonds consists of two parts. The first part contains 14 registers of the movement of people and goods through the Lazarettos in Ploče, in the eastern suburb of Dubrovnik (18th century). Those registers were kept by the Captain of Lazarettos. The registers contain the following information: the date of the passenger's entry into the Lazarettos, the name and surname of the passenger, the name of the place from which the passenger arrived, the list of merchandise the passenger had brought, the number of the specific lazaretto where the passenger would be quarantined and the date of release from quarantine. The second part of the fonds (16th-18th centuries) consists of volumes with the following data: provisions of the Office of Public Health and the Senate which were related to the protection against the plague, expenses of the Office, investigations conducted by the Office of Public Health against persons who violated the measures for the protection against plague, and lists of health officials who were deployed throughout the territory of the Republic at the time of the danger of the plague.

The registers containing data of the movement of people and goods through the Lazarettos in the 18th century are very important to the research of the business affairs of the Jews from Sarajevo as well as for understanding their relationships with the Jews from Dubrovnik. Many of these records testify about the arrival of Jews in the Lazarettos almost all of whom came from Sarajevo (e.g., vol. 11a, ff. 10v, 39, 39v, 41v, 48v, 59, 64, 74v, 76, 80, 81, 82c, 85, 91c, 97, 101c, 102c, 103, 104, 109, 116c, 127). The records show that most of these Jews were originally from Dubrovnik and were returning home from Sarajevo, and there are also records of Jews from Sarajevo who would come to Dubrovnik for private or business reasons. There are also references to members of the following Jewish families: Abinun, Abramović, Altarac, Asser, Atias, Campos, Cohen, Danon, David, Escenasi, Fermo, Finzi, Forte, Franco, Gabai, Gaon, Haion, Joel, Jona, Levi, Montiglio, Musafia, Musafir, Papić (Pappo), Pinto, Saba, Saltiel, Seferović, Tedeschi, Tolentino, Vitali and Zevi. Apart from the Lazarettos, other facilities located in the suburbs of Ploče were also used for the purposes of quarantine. Among those buildings was the house of a famous Dubrovnik merchant Samuel Ambonetti. His house has been used as a quarantine area since the late 1750s, and the data shows that it was named the “old Ambonetti lazaretto” (e.g., vol. 7, f. 13v). There are less references to Jews in the second part of the fonds. Those references are primarily to Jewish bookbinders who bound books for the needs of the Office of Public Health. There are also references to the taxes imposed on the Dubrovnik Orthodox community and sea captains from Dubrovnik as well as taxes imposed on the Jewish community for the costs of protection against a very strong plague epidemics that ravaged the Dubrovnik hinterland in the 60s and the 80s of the 18th centuries (e.g., vol. 2, August 20, 1767). Particularly interesting is the reference to Abram Abuaf, who in 1691 during the epidemic, treated plague patients in the city of Dubrovnik (vol. 7, f. 12).