The series contains state letters and instructions to Ragusan ambassadors, tribute ambassadors, consuls, administrators of Dubrovnik consulates, charges d’affairs, and merchants in the cities of the Ottoman Empire in the period from the middle of the 14th to the beginning of the 19th century. The cities that are mostly referred to in the series are: Istanbul, Jedrene, Belgrade, Vlora, Volos, Alexandria, Banja Luka, Sarajevo, Travnik, Mostar and Pljevlja. The series also includes letters from the authorities of the Dubrovnik Republic to various Ottoman dignitaries and officials, from Grand Viziers in Istanbul to kadis in the Dubrovnik neighbourhood.

The series is very important for the research of the history of the Jewish people in the Ottoman Empire, as well as for any attempted analysis of their cooperation with the Jews from the Republic. The series contains state letters to the consuls of the Republic in Vlora, who were Jewish (16th and 17th centuries). The following names of the consuls are referenced: Isach Trincha, who is only referenced to in one letter (vol. 20, f. 15v), Jacob Coduto, Daniel Coduto, Zacharia Graziano, Angiolo Coduto (vol. 28-34, 37, 42-45, 47-50). In addition to the names previously mentioned, there are several other Vlora Jews that are mentioned in the documents from the 16th century. The series also contains several letters from the authorities of the Republic to their tribute ambassadors, in which there are references to Gracia Mendes. In 1552, she travelled to Istanbul via Dubrovnik. The data shows that she conducted her business from Istanbul, using the port of Dubrovnik to trade with Western countries till she died. The ambassadors of the Republic would regularly visit her and bring her letters from the authorities. According to the records, she would lend money to the ambassadors and the authorities of the Republic would then reimburse the money to her representatives in Dubrovnik, Isaac Ergas and Abner Alfarin (vol. 26-29). Other Istanbul Jews also lent money to Dubrovnik tax collectors, and the authorities would then reimburse it to their relatives in Dubrovnik. For example, in 1576, Samuel Ergas wrote a letter of recommendation to two Jews from Istanbul, Judi Algasi and Samuel Celef, asking them to lend money to the emissaries of the Republic if that was deemed necessary (vol. 33, f. 67v). Dubrovnik merchants owned real estate in some Ottoman cities and would often rent it, especially in Sofia, to Jewish merchants. Related to this fact, there are several references to conflicts that occurred among those merchants. Even though the series provides evidence to some other conflicts in which Jewish merchants were involved, it also provides evidence of different forms of successful cooperation with Jewish merchants. The authorities of the Dubrovnik Republic evidently cooperated with Jewish merchants who were influential at the sultan's court (e.g., vol. 31, ff. 25v-26v). One of those merchants, Conort, whose name is not referenced in this series, worked in the 80s of the 18th century as a dragoman of Dubrovnik ambassadors at the Sublime Porte (vol. 103, ff. 113v, 121v).