The series contains letters from the authorities of the Republic to foreign rulers and other politicians, popes, and cardinals, as well as letters and instructions to Dubrovnik ambassadors, consuls, administrators of Dubrovnik consulates, charges d'affaires, and to merchants from different Western European countries and cities. Mostly referenced cities are those from the Apennine Peninsula such as Venice, Rome, Ancona, Naples, Genoa, Barletta, as well as other European cities (Vienna, London, Madrid, Paris) and the cities of Morocco, Tripoli (present-day Libya), Tunisia and Algeria. The documents in the series date from the 60s of the 16th century until the beginning of the 19th century.

The series is very important for the research of the history of converts and Jewish people of North Africa. It contains many letters sent by the authorities of the Republic to certain Jews, such as Abram Bussara, Raphael Jacob Bussara and Naftali Busnaco, who were administrators of the Dubrovnik Consulate in Algeria (vols. 76-78, 89, 90, 108, 109, 119, 125-127, 129 -131, 133-137; 1763, 1770, 1778, 1779, 1790-1792, 1794-1802). Some letters of the authorities of the Republic to the Dubrovnik consul in Vlora, Jacob Coduto can also be also found in this series (vol. 1, 2). There are other references to Jews in state letters to popes, cardinals, and Dubrovnik diplomatic representatives in Rome. Jewish physicians, who had their practice in Dubrovnik in the 16th century, are the primary topic of these letters. The data indicate that this was the reason why the Holy See would protest to the authorities of the Republic (i.e., vol. 4, ff. 242-245v). Ragusan authorities had to justify themselves to the Holy See also because of converts who returned in Dubrovnik to their original faith, as well as because of Christian maids who served in Jewish families (i.e., vol. 3, ff. 157-157v).